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The effect of blister packaging on shelf life

2021-04-11

The effect of blister packaging on shelf life


As a common medical packaging, blister packaging is widely used in all kinds of pharmaceutical packaging that we take every day. In addition to ordinary pharmaceutical tablets, suppositories, capsules and other pharmaceutical products, it is also widely used in food, cosmetics, and toys.  Gifts, mechanical and electrical parts packaging, has the advantages of easy to use, transparent and intuitive, light weight and so on.


Its main material is a kind of resin called pvc. Its main feature is good hardness, gloss and transparency. Many users think it is an excellent packaging. But when we examine the barrier performance alone, we will find that the facts are not as good as imagined.

If a certain medical product is extremely sensitive to oxygen and water vapor, then it is obvious that this kind of medicine is not suitable for packaging such as PVC, so we will see many pharmaceutical companies begin to add a layer of aluminum outside the blister package. However, in fact, because the packaging environment of the medicine is not a vacuum environment, the aluminum bag is still filled with air, which will still form a penetration effect, and the medicine in the blister package will still be oxidized by oxygen. For this kind of process, the best supplement method is outside The package is filled with nitrogen. As nitrogen has buffering and displacement effects, it will greatly reduce the influence of oxygen on the sample in the blister. However, many pharmaceutical manufacturers do not realize and do this.

Then a more expensive way to protect drugs also appeared on the market is the so-called double-aluminum packaging, the so-called double-aluminum packaging, as the name suggests, is to use aluminum-plastic composite film instead of PVC rigid sheet blister, and then use ultra-high barrier properties on the outer bag. The aluminum-plastic packaging can block water and oxygen and can also play a role in preventing light. However, for the same reason, if the packaging process is not carried out in a buffer environment, the packaging will still contain 21% oxygen, which will act on sensitive drugs and cause The medicine has deteriorated.